Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | GOT1 | P17174 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141639 | 0.83 | GPR119 (0.43) | LMNA | |
| SCHEMBL20142178 | 0.80 | KEAP1 (0.36) | KEAP1GHSRBCHEGOT1LMNA | |
| Trifluoroacetic Acid SCHEMBL20142184 | 0.80 | IRAK4 (0.41) | — | |
| SCHEMBL20156815 | 0.80 | ALDH1A1 (0.40) | KMT2AKDM4E | |
| SCHEMBL20141537 | 0.71 | KEAP1 (0.47) | KEAP1BCHEGOT1KDM4E | |
| SCHEMBL20156813 | 0.71 | MTOR (0.47) | MEN1KMT2ATACR3KDM4E | |
| SCHEMBL30359952 | 0.69 | BRD4 (0.32) | — | |
| SCHEMBL6097862 | 0.69 | KEAP1 (0.41) | TP53KEAP1GHSRBCHEKDM4E | |
| SCHEMBL5369598 | 0.67 | GRM5 (0.60) | L3MBTL1TP53TACR3GRM5 | |
| SCHEMBL1225685 | 0.67 | ALDH1A1 (0.51) | KMT2AGHSRLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |