Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014255 | 0.86 | HTT (0.41) | TSHRHTTALDH1A1TP53CYP1A2 | |
| SCHEMBL2018304 | 0.85 | HTT (0.40) | TSHRHTTALDH1A1TP53CYP1A2 | |
| SCHEMBL2016749 | 0.85 | ACSS2 (0.41) | TSHRHTTALDH1A1TP53CYP1A2 | |
| Iodide SCHEMBL2015385 | 0.84 | SCNN1A (0.39) | FKBP1ATSHRALDH1A1NPSR1TP53 | |
| SCHEMBL2018137 | 0.83 | ACSS2 (0.39) | TSHRHTTTP53CYP1A2CYP3A4 | |
| SCHEMBL2020338 | 0.83 | HTT (0.46) | TSHRHTTALDH1A1TP53CYP1A2 | |
| SCHEMBL2013943 | 0.81 | ACSS2 (0.38) | HTTKMT2AACSS2SCNN1A | |
| SCHEMBL2040435 | 0.80 | HTT (0.45) | TSHRHTTALDH1A1TP53CYP1A2 | |
| SCHEMBL16882399 | 0.80 | MAPT (0.37) | TSHRHTTPIK3CDACSS2 | |
| SCHEMBL17937169 | 0.79 | PTGES (0.38) | HTTALDH1A1PIK3CDKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |