Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCNN1A | P37088 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013943 | 0.95 | ACSS2 (0.38) | ACSS2HTTHDAC1HDAC8KCNH2 | |
| SCHEMBL2016749 | 0.93 | ACSS2 (0.41) | ACSS2HTTSCNN1ATP53MAPT | |
| SCHEMBL2014255 | 0.89 | HTT (0.41) | ACSS2HTTSCNN1ATP53MAPT | |
| SCHEMBL2018304 | 0.87 | HTT (0.40) | ACSS2HTTSCNN1ATP53CYP1A2 | |
| SCHEMBL2020338 | 0.87 | HTT (0.46) | ACSS2HTTSCNN1ATP53MAPT | |
| SCHEMBL2018751 | 0.83 | SCNN1A (0.41) | CXCR3KCNH2SCNN1ATP53CYP1A2 | |
| SCHEMBL2014371 | 0.83 | FKBP1A (0.41) | ACSS2HTTSCNN1ATP53CYP1A2 | |
| Iodide SCHEMBL2016021 | 0.83 | SCNN1A (0.40) | CXCR3KCNH2SCNN1ATP53CYP1A2 | |
| SCHEMBL2040435 | 0.82 | HTT (0.45) | ACSS2HTTTP53MAPTCYP1A2 | |
| SCHEMBL2016331 | 0.81 | HTT (0.52) | ACSS2HTTSCNN1ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |