Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 11/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144970 | 0.77 | HCRTR1 (0.52) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL20144983 | 0.72 | HCRTR1 (0.52) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL20145164 | 0.72 | HCRTR1 (0.52) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL20145228 | 0.71 | IL1B (0.54) | CCNKCDK12 | |
| SCHEMBL20144912 | 0.70 | HCRTR1 (0.56) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL20145167 | 0.69 | CCNK (0.48) | HCRTR1HCRTR2CCNKCDK12TSHR | |
| SCHEMBL16147979 | 0.68 | HCRTR1 (0.76) | HCRTR1HCRTR2 | |
| SCHEMBL20145009 | 0.67 | GFER (0.49) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL15739537 | 0.65 | HCAR3 (0.56) | PDE10ACCNKCDK12TSHRKDM4E | |
| SCHEMBL16147928 | 0.64 | HCRTR1 (0.68) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |