Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | TACR2 | P21452 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014784 | 1.00 | CYP3A4 (0.49) | CYP3A4CYP2D6CYP2C9THRATHRB | |
| SCHEMBL2089165 | 0.91 | THRA (0.54) | CYP3A4THRATHRBHPGDALDH1A1 | |
| SCHEMBL2092762 | 0.89 | THRA (0.56) | CYP3A4THRATHRBALDH1A1ESR1 | |
| SCHEMBL18092321 | 0.89 | THRA (0.56) | CYP3A4THRATHRBALDH1A1ESR1 | |
| SCHEMBL28334027 | 0.88 | CYP3A4 (0.44) | CYP3A4CYP2D6CYP2C9THRATHRB | |
| SCHEMBL5546165 | 0.85 | HPGD (0.51) | CYP3A4CYP2D6CYP2C9THRATHRB | |
| SCHEMBL20420637 | 0.80 | ESR1 (0.61) | CYP3A4CYP2D6CYP2C9ALDH1A1ESR1 | |
| SCHEMBL8509669 | 0.80 | ESR1 (0.61) | CYP3A4CYP2D6CYP2C9ALDH1A1ESR1 | |
| SCHEMBL13904867 | 0.80 | ESR1 (0.61) | CYP3A4CYP2D6CYP2C9ALDH1A1ESR1 | |
| SCHEMBL20420626 | 0.80 | ESR1 (0.61) | CYP3A4CYP2D6CYP2C9ALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3621958-B1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2024-07-10 | — | — | EP | claimed |
| EP-3268375-B1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2022-06-15 | — | — | EP | claimed |
| EP-3071576-B9 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-12-22 | — | — | EP | claimed |
| EP-3071576-B1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-08-18 | — | — | EP | claimed |
| EP-3621958-A1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | Transitions Optical, Ltd. (IE) | 2020-03-18 | — | — | EP | claimed |
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-02-13 | — | — | US | claimed |
| WO-2018206096-A1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL, LTD. (IE) | 2018-11-15 | — | — | WO | claimed |
| EP-3071551-A1 | FUSED RING INDENO COMPOUNDS FOR PREPARATION OF PHOTOCHROMIC COMPOUNDS | Transitions Optical, Inc. (US) | 2016-09-28 | — | — | EP | claimed |
| EP-3071576-A1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | Transitions Optical, Inc. (US) | 2016-09-28 | — | — | EP | claimed |
| CN-105829283-A | Fused ring indeno compounds for preparation of photochromic compounds | 光学转变公司 | 2016-08-03 | — | — | CN | claimed |
| US-9051332-B1 | Photochromic indeno-fused ring pyran compounds | TRANSITIONS OPTICAL, INC. (US) | 2015-06-09 | — | — | US | claimed |
| WO-2015077141-A1 | FUSED RING INDENO COMPOUNDS FOR PREPARATION OF PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2015-05-28 | — | — | WO | claimed |
| WO-2015077264-A1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2015-05-28 | — | — | WO | claimed |
| US-20150141661-A1 | Photochromic Indeno-Fused Ring Pyran Compounds | TRANSITIONS OPTICAL, INC. (US) | 2015-05-21 | — | — | US | claimed |
| US-9029565-B1 | Fused ring indeno compounds for preparation of photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | claimed |
| US-8545984-B2 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2013-10-01 | — | — | US | claimed |
| US-20110129678-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-02 | — | — | US | claimed |
| EP-1639058-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2005005570-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | claimed |
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL LIMITED (IE) | 2005-01-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | ALDH1A2, RB1, INCENP | CYP3A4 648/4885CYP2D6 39/4885CYP2C9 884/4885 |
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | CCND1, CCND3, CCND2 | CYP3A4 658/4885CYP2D6 155/4885CYP2C9 889/4885 |
| US-20110129678-A1 | Photochromic compounds and compositions | CRY2, CRY1, PPOX | CYP3A4 595/4885CYP2D6 616/4885CYP2C9 167/4885 |
| US-20150141661-A1 | Photochromic Indeno-Fused Ring Pyran Compounds | INF2, INCENP, RB1 | CYP3A4 1035/4885CYP2D6 476/4885CYP2C9 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.