Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032786 | 0.89 | ALDH1A1 (0.56) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL3227122 | 0.89 | KMT2A (0.70) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL3227131 | 0.89 | KMT2A (0.70) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL7570506 | 0.83 | ALDH1A1 (0.56) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL18794812 | 0.79 | ALDH1A1 (0.69) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL30253420 | 0.78 | ALDH1A1 (0.51) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL1791317 | 0.75 | KMT2A (0.58) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL6096659 | 0.74 | ALDH1A1 (0.56) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL18794875 | 0.74 | ALDH1A1 (0.56) | KMT2AALDH1A1MCOLN3POLBLMNA | |
| SCHEMBL3778136 | 0.74 | ALDH1A1 (0.59) | KMT2AALDH1A1MCOLN3POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11357231-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION LLC (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200383330-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2020-12-10 | — | — | US | disclosed |
| US-10750745-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190166842-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2019-06-06 | — | — | US | disclosed |
| US-10206400-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2019-02-19 | — | — | US | disclosed |
| US-20170152250-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2017-06-01 | — | — | US | disclosed |
| US-9609869-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2017-04-04 | — | — | US | disclosed |
| US-20140228577-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-14 | — | — | US | disclosed |
| US-8735362-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2014-05-27 | — | — | US | disclosed |
| EP-2507230-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | Syngenta Participations AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| US-20120238517-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2012-09-20 | — | — | US | disclosed |
| WO-2011067272-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228577-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | KMT2A 2824/4885ALDH1A1 238/4885MCOLN3 662/4885 |
| US-20200383330-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CYP4X1, NPY4R, CASP3 | KMT2A 2510/4885ALDH1A1 1543/4885MCOLN3 2068/4885 |
| US-20120238517-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | KMT2A 2686/4885ALDH1A1 412/4885MCOLN3 704/4885 |
| US-10206400-B2 | Insecticidal compounds based on isoxazoline derivatives | CHRM1, ACHE, CHRM2 | KMT2A 2824/4885ALDH1A1 238/4885MCOLN3 662/4885 |
| US-11357231-B2 | Insecticidal compounds based on isoxazoline derivatives | CYP4X1, NPY4R, CASP3 | KMT2A 2510/4885ALDH1A1 1543/4885MCOLN3 2068/4885 |
| US-20170152250-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | KMT2A 2824/4885ALDH1A1 238/4885MCOLN3 662/4885 |
| US-10750745-B2 | Insecticidal compounds based on isoxazoline derivatives | CHRM1, ACHE, CHRM2 | KMT2A 2824/4885ALDH1A1 238/4885MCOLN3 662/4885 |
| US-20190166842-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | KMT2A 2824/4885ALDH1A1 238/4885MCOLN3 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.