Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | QDPR | P09417 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002280 | 0.84 | TACR1 (0.40) | RORCDPP4DPP7TACR1TACR3 | |
| SCHEMBL20002902 | 0.76 | ALDH1A1 (0.47) | RORCMEN1KMT2AALDH1A1 | |
| SCHEMBL20002167 | 0.75 | KDM1A (0.40) | RORCALDH1A1KDM1AMAOB | |
| SCHEMBL20002664 | 0.72 | TSHR (0.41) | KMT2A | |
| SCHEMBL20002286 | 0.72 | TACR1 (0.45) | RORCTACR1TACR3 | |
| SCHEMBL20384198 | 0.72 | MEN1 (0.36) | IDO1MEN1KMT2AALDH1A1KDM1A | |
| SCHEMBL20002429 | 0.71 | RORC (0.41) | RORCTACR1 | |
| SCHEMBL20002969 | 0.71 | NOTUM (0.45) | RORCKMT2AALDH1A1 | |
| SCHEMBL20002669 | 0.71 | NOTUM (0.45) | RORCKMT2AALDH1A1 | |
| SCHEMBL20003049 | 0.71 | AKR1C3 (0.51) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |