SCHEMBL20149256

SCHEMBL20149256

CC(C)S(=O)(=O)c1c(F)cc(N)cc1F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.38
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA7 P43166 2/20 0.34
CA13 Q8N1Q1 1/20 0.34
FEN1 P39748 5/20 0.33
ALOX5AP P20292 3/20 0.33
PTGS1 P23219 2/20 0.33
PTGS2 P35354 2/20 0.33
PKM P14618 3/20 0.32
CXCR2 P25025 1/20 0.31
CA4 P22748 1/20 0.31
CA6 P23280 1/20 0.31
CA5A P35218 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
CA5B Q9Y2D0 1/20 0.31
PSEN1 P49768 1/20 0.30
PSEN2 P49810 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16747614 0.81 SLC6A4 (0.34) PTGS1PTGS2
SCHEMBL20223491 0.79 CA12 (0.35) L3MBTL1CA12CA1CA2CA7
SCHEMBL20149255 0.76 CASP1 (0.41) L3MBTL1CA12CA1CA2CA7
SCHEMBL20149266 0.75 L3MBTL1 (0.43) L3MBTL1CA2FEN1ALOX5APNPC1
SCHEMBL14443235 0.74 PKM (0.45) L3MBTL1PTGS1PTGS2PKMCXCR2
SCHEMBL31618986 0.73 CA1 (0.39) CA12CA1CA2CA7CA13
SCHEMBL20226594 0.72 GAA (0.42) CA12CA1CA2CA7CA13
SCHEMBL12325549 0.71 ALOX5AP (0.42) L3MBTL1FEN1ALOX5APPSEN1PSEN2
SCHEMBL18531234 0.70 ALDH1A1 (0.35) CA12CA1CA2CA7CA13
SCHEMBL25628842 0.70 PTGS1 (0.36) L3MBTL1FEN1ALOX5APPTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11760775-B2 Steroids and protein-conjugates thereof REGENERON PHARMACEUTICALS, INC. 2023-09-19 US disclosed
WO-2018089373-A9 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2018-07-12 WO disclosed
US-20180155389-A1 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. 2018-06-07 US disclosed
WO-2018089373-A2 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180155389-A1 STEROIDS AND PROTEIN-CONJUGATES THEREOF SERPINA6, NR3C1, NR3C2 L3MBTL1 2840/4885CA12 3431/4885CA1 3880/4885
US-11760775-B2 Steroids and protein-conjugates thereof SERPINA6, NR3C1, NR3C2 L3MBTL1 2855/4885CA12 3598/4885CA1 3944/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.