Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015354 | 0.85 | PPARG (0.52) | PPARGACSS2TSHRKDM4EGAA | |
| SCHEMBL2019390 | 0.81 | BACE1 (0.41) | PPARGRPS6KA5ACSS2AAK1TNF | |
| SCHEMBL2018088 | 0.79 | TNF (0.53) | ACSS2TNFTSHRKDM4EPOLB | |
| SCHEMBL2013679 | 0.78 | PPARG (0.45) | PPARGACSS2TNFTSHRKDM4E | |
| SCHEMBL2020767 | 0.78 | ACSS2 (0.54) | ACSS2TNFTSHRKDM4EGAA | |
| SCHEMBL2020983 | 0.76 | LMNA (0.50) | PPARGTSHRGAAMAPT | |
| SCHEMBL2020612 | 0.75 | ACSS2 (0.56) | ACSS2POLBMAPT | |
| SCHEMBL2020859 | 0.74 | TDP1 (0.53) | PPARGRPS6KA5TSHRKDM4EPOLB | |
| SCHEMBL2017366 | 0.73 | POLB (0.64) | TNFTSHRKDM4EPOLBGAA | |
| SCHEMBL2018235 | 0.71 | ACSS2 (0.38) | ACSS2TNFTSHRKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |