Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015354 | 0.80 | PPARG (0.52) | LMNAPPARGMAPTTSHRNPC1 | |
| SCHEMBL2020612 | 0.77 | ACSS2 (0.56) | MAPTNPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2015276 | 0.76 | PPARG (0.49) | PPARGMAPTTSHRGAA | |
| Hydrochloric Acid SCHEMBL30281586 | 0.75 | SMN1; SMN2 (0.44) | PKMPPARGMAPTPIK3R1PIK3CA | |
| Hydrochloric Acid SCHEMBL29205499 | 0.75 | SMN1; SMN2 (0.44) | PKMPPARGMAPTPIK3R1PIK3CA | |
| SCHEMBL2017366 | 0.73 | POLB (0.64) | LMNAPKMMAPK1MAPTTSHR | |
| SCHEMBL12635705 | 0.72 | TSPO (0.41) | ABL1TSPO | |
| SCHEMBL2018088 | 0.72 | TNF (0.53) | PKMMAPTTSHRNPC1RAB9A | |
| SCHEMBL2019390 | 0.72 | BACE1 (0.41) | PPARGTSHRMAP4K4 | |
| SCHEMBL2013679 | 0.71 | PPARG (0.45) | LMNAPKMMAPK1PPARGTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |