Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24413933 | 0.87 | PKM (0.49) | PKMTHRATHRBHSP90AB1HMGCR | |
| SCHEMBL7953584 | 0.77 | HSP90AB1 (0.45) | HSP90AB1HMGCRHSD17B10KDM4EMAPT | |
| SCHEMBL24413663 | 0.77 | PKM (0.53) | PKMHSP90AB1HMGCRHSD17B10KDM4E | |
| SCHEMBL4841923 | 0.74 | HMGCR (0.58) | PKMHSP90AB1HMGCRHSD17B10KDM4E | |
| SCHEMBL18432610 | 0.73 | MAPT (0.40) | HSD17B10KDM4EMAPTGAATSHR | |
| SCHEMBL13640243 | 0.73 | PKM (0.42) | PKMHSP90AB1HMGCRHSD17B10KDM4E | |
| SCHEMBL13574288 | 0.73 | ALOX5 (0.41) | PKMTHRBHSP90AB1HSD17B10KDM4E | |
| SCHEMBL10518482 | 0.72 | HSP90AB1 (0.41) | HSP90AB1HMGCRHSD17B10KDM4EMAPT | |
| SCHEMBL270136 | 0.72 | GABRA1 (0.45) | HSP90AB1MAPTTSHRMEN1CYP3A4 | |
| SCHEMBL13623381 | 0.72 | GABRA1 (0.42) | PKMHSP90AB1TSHRCYP3A4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089904-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | 3-V BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |