Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23252673 | 0.81 | HSP90AA1 (0.58) | HPGDHSP90AA1HSP90AB1MLYCDGABRA1 | |
| SCHEMBL20157077 | 0.78 | TP53 (0.37) | HPGDMLYCDGABRA1GABRB2TP53 | |
| SCHEMBL8282807 | 0.77 | MLYCD (0.39) | HPGDMLYCDTP53EGFRERBB2 | |
| SCHEMBL20157264 | 0.76 | TP53 (0.38) | HPGDHSP90AA1HSP90AB1MLYCDGABRA1 | |
| SCHEMBL22065201 | 0.74 | TDP1 (0.42) | HPGDALDH1A1MEN1KMT2AGAA | |
| SCHEMBL20157110 | 0.74 | HPGD (0.36) | HPGDMLYCDTP53LMNASMN1; SMN2 | |
| SCHEMBL20157023 | 0.72 | TP53 (0.35) | HPGDMLYCDGABRA1GABRB2TP53 | |
| SCHEMBL22066370 | 0.72 | TDP1 (0.41) | HPGDLMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21078085 | 0.71 | TP53 (0.47) | HPGDTP53EGFRLMNASMN1; SMN2 | |
| SCHEMBL3258577 | 0.71 | ALDH1A1 (0.52) | TP53SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |