Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | DRD4 | P21917 | 7/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157179 | 0.83 | HSP90AB1 (0.39) | THRBDPP4DRD2DRD4GRM5 | |
| SCHEMBL20157218 | 0.81 | HTR7 (0.40) | THRBDPP4DRD2DRD4DRD3 | |
| SCHEMBL20156862 | 0.71 | DRD2 (0.45) | THRBDRD2DRD4GRM5DRD3 | |
| SCHEMBL20156961 | 0.68 | DRD2 (0.49) | DRD2DRD4GRM5DRD3MC4R | |
| SCHEMBL13898671 | 0.68 | MC4R (0.51) | DRD2DRD4GRM5DRD3MC4R | |
| SCHEMBL3088832 | 0.67 | DRD4 (0.54) | DRD2DRD4GRM5DRD3HTR7 | |
| SCHEMBL14355275 | 0.65 | HSP90AB1 (0.66) | DRD2DRD3HTR7HTR1AHSP90AB1 | |
| SCHEMBL8760562 | 0.65 | DRD2 (0.43) | DPP4DRD2DRD4GRM5DRD3 | |
| SCHEMBL20156977 | 0.65 | HTR7 (0.47) | THRBDRD2DRD4GRM5DRD3 | |
| SCHEMBL9118895 | 0.63 | DRD2 (0.45) | THRBDRD2DRD4GRM5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |