Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | LPL | P06858 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21354518 | 0.88 | CXCR2 (0.38) | CXCR2GAAALDH1A1LMNAMETAP2 | |
| SCHEMBL21362390 | 0.81 | UCHL1 (0.50) | GAAALDH1A1LMNAUCHL1MAPT | |
| SCHEMBL20157840 | 0.81 | HTT (0.48) | CXCR2GAAALDH1A1LMNAUCHL1 | |
| SCHEMBL21362596 | 0.79 | LPL (0.42) | CXCR2GAAALDH1A1LMNALPL | |
| SCHEMBL20157420 | 0.78 | CXCR2 (0.36) | CXCR2GAAALDH1A1LMNAUCHL1 | |
| SCHEMBL20157831 | 0.78 | CXCR2 (0.40) | CXCR2GAAALDH1A1LMNAUCHL1 | |
| SCHEMBL20157565 | 0.78 | LMNA (0.43) | CXCR2LMNAUCHL1LPLLIPG | |
| SCHEMBL28804052 | 0.78 | P4HB (0.39) | ALDH1A1LMNAUCHL1LPLLIPG | |
| SCHEMBL29756388 | 0.78 | P4HB (0.39) | ALDH1A1LMNAUCHL1LPLLIPG | |
| SCHEMBL20157558 | 0.77 | CXCR2 (0.37) | CXCR2LPLLIPGMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |