Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20164006 | 1.00 | ALDH1A1 (0.43) | ALDH1A1LMNAMEN1KMT2ACNR2 | |
| SCHEMBL25418133 | 0.84 | VNN1 (0.36) | VNN1 | |
| SCHEMBL31663374 | 0.76 | MEN1 (0.41) | ALDH1A1LMNAMEN1KMT2ACNR2 | |
| SCHEMBL5527373 | 0.74 | OPRD1 (0.46) | CYP2D6 | |
| SCHEMBL22688968 | 0.73 | OPRM1 (0.38) | ALDH1A1HPGD | |
| SCHEMBL25419787 | 0.73 | ALDH1A1 (0.48) | ALDH1A1LMNAMEN1KMT2ACNR2 | |
| SCHEMBL21619228 | 0.72 | HSD11B1 (0.39) | KMT2ASMN1; SMN2 | |
| SCHEMBL7984936 | 0.71 | EPHX1 (0.39) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23247584 | 0.71 | JAK3 (0.35) | — | |
| SCHEMBL23247492 | 0.69 | HCRTR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11452293-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2022-09-27 | — | — | US | disclosed |
| US-20200236936-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2020-07-30 | — | — | US | disclosed |
| US-10667515-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190200611-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2019-07-04 | — | — | US | disclosed |
| US-20180139961-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10667515-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | AAAS, NANS, CIAPIN1 | ALDH1A1 2014/4885LMNA 1322/4885MEN1 2220/4885 |
| US-20190200611-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | ALDH1A1 2014/4885LMNA 1322/4885MEN1 2220/4885 |
| US-20200236936-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | ALDH1A1 2014/4885LMNA 1322/4885MEN1 2220/4885 |
| US-11452293-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | AAAS, NANS, CIAPIN1 | ALDH1A1 2014/4885LMNA 1322/4885MEN1 2220/4885 |
| US-20180139961-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | ALDH1A1 2014/4885LMNA 1322/4885MEN1 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.