Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038718 | 0.85 | LMNA (0.33) | SMN1; SMN2NPC1RAB9APOLBHSD11B1 | |
| SCHEMBL2012604 | 0.82 | FKBP1A (0.32) | SMN1; SMN2NPC1RAB9APOLBHSD11B1 | |
| SCHEMBL2014915 | 0.68 | ALDH1A1 (0.46) | SMN1; SMN2POLBMAPTALDH1A1TP53 | |
| SCHEMBL2013111 | 0.65 | KDM4E (0.35) | SMN1; SMN2NPC1RAB9APOLBLMNA | |
| SCHEMBL22499881 | 0.62 | EPHX2 (0.41) | SMN1; SMN2NPC1RAB9ALMNAMAPT | |
| SCHEMBL2014478 | 0.62 | P2RX7 (0.36) | SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2034061 | 0.62 | P2RX7 (0.36) | SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2015104 | 0.61 | MAPT (0.45) | SMN1; SMN2NPC1RAB9APOLBLMNA | |
| SCHEMBL22499927 | 0.60 | EPHX2 (0.40) | SMN1; SMN2NPC1RAB9ALMNAMAPT | |
| SCHEMBL2016483 | 0.60 | MAPT (0.44) | SMN1; SMN2NPC1RAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513069-A1 | ANTIFUNGAL COMPOUNDS | Katholieke Universiteit Leuven (BE) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011072345-A1 | ANTIFUNGAL COMPOUNDS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2011-06-23 | — | — | WO | disclosed |