Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | IAPP | P10997 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170918 | 0.81 | IAPP (0.36) | IAPPMPOSLC6A4 | |
| SCHEMBL9626599 | 0.74 | MGLL (0.36) | MMP13MPOSLC6A4AAK1 | |
| SCHEMBL7651312 | 0.66 | HTR1A (0.47) | SLC6A4 | |
| SCHEMBL3071452 | 0.65 | MTNR1A (0.54) | IAPPMPOSLC6A4 | |
| SCHEMBL24812914 | 0.64 | CTSK (0.52) | — | |
| SCHEMBL30049273 | 0.64 | CTSK (0.52) | — | |
| SCHEMBL29178324 | 0.64 | CTSK (0.52) | — | |
| SCHEMBL2821947 | 0.64 | CYP4F2 (0.47) | IAPP | |
| SCHEMBL8600783 | 0.64 | NQO2 (0.52) | MPOSLC6A4 | |
| SCHEMBL27770725 | 0.63 | TDP1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970334-B1 | MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | BIOGEN MA INC (US) | 2018-05-23 | — | — | EP | disclosed |