Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170916 | 0.81 | MMP13 (0.34) | IAPPMPOSLC6A4 | |
| SCHEMBL3071452 | 0.71 | MTNR1A (0.54) | IAPPMPOSLC6A4MGLLAKR1B1 | |
| SCHEMBL7117086 | 0.68 | CYP4F2 (0.49) | IAPPMPOSLC6A4NPC1PKM | |
| SCHEMBL27446763 | 0.67 | TSHR (0.46) | IAPPMPOSLC6A4NPC1PKM | |
| SCHEMBL29191321 | 0.66 | IAPP (0.58) | IAPPMPOSLC6A4NPC1PKM | |
| SCHEMBL9628209 | 0.65 | MPO (0.49) | MPOSLC6A4MGLLKDM4EHTR1A | |
| SCHEMBL3068210 | 0.65 | HSPA5 (0.48) | IAPPMPOSLC6A4NPC1PKM | |
| SCHEMBL27530341 | 0.64 | TAAR1 (0.55) | IAPPMPOSLC6A4MGLLAKR1B1 | |
| SCHEMBL1827150 | 0.64 | AKR1B1 (0.61) | IAPPMPOSLC6A4MGLLAKR1B1 | |
| SCHEMBL31155814 | 0.64 | CYP4F2 (0.55) | IAPPMPOSLC6A4NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970334-B1 | MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | BIOGEN MA INC (US) | 2018-05-23 | — | — | EP | disclosed |