Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.69 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | CTSK | P43235 | 5/20 | 0.58 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.57 |
| ▸ | CTSB | P07858 | 2/20 | 0.56 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | CTSS | P25774 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21318267 | 0.92 | CTSL (0.69) | CTSLCAPN1CTSKCTSBCTSS | |
| SCHEMBL20828108 | 0.92 | CAPN1 (0.71) | CTSLCAPN1PTPN1CTSKHTRA1 | |
| SCHEMBL30064827 | 0.91 | CAPN1 (0.62) | CTSLCAPN1CTSKCTSBMMP3 | |
| SCHEMBL16862451 | 0.89 | CTSL (0.72) | CTSLCTSKCTSBCTSS | |
| SCHEMBL31705215 | 0.89 | CAPN1 (0.74) | CTSLCAPN1PTPN1CTSKHTRA1 | |
| Hydrochloric Acid SCHEMBL16862483 | 0.88 | CTSL (0.70) | CTSLCTSKCTSBCTSS | |
| SCHEMBL31664357 | 0.88 | CAPN1 (0.60) | CTSLCAPN1CTSKHTRA1CTSB | |
| SCHEMBL1661314 | 0.86 | CTSL (0.68) | CTSLCTSKCTSBCTSS | |
| SCHEMBL7999200 | 0.86 | CTSL (0.51) | CTSLREN | |
| SCHEMBL20173867 | 0.86 | REN (0.62) | CTSLCAPN1PTPN1CTSKREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889543-B2 | Fine-tune modulators of neuronal excitability for neuropsychiatric disorders | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-01-12 | — | — | US | disclosed |
| US-20190270705-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-09-05 | — | — | US | disclosed |
| WO-2018094335-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10889543-B2 | Fine-tune modulators of neuronal excitability for neuropsychiatric disorders | CACNG6, KCNN3, SCN1B | CTSL 4409/4885CAPN1 2273/4885PTPN1 2199/4885 |
| US-20190270705-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | CACNG6, KCNN3, SCN1B | CTSL 4409/4885CAPN1 2273/4885PTPN1 2199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.