Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25459969 | 0.88 | CTSK (0.48) | MMP1MMP3MMP9CA2MEN1 | |
| SCHEMBL30565196 | 0.84 | MEN1 (0.53) | MMP1MMP3MMP9CA1CA2 | |
| SCHEMBL30317668 | 0.83 | CA1 (0.49) | MMP1MMP3MMP9CA1CA2 | |
| SCHEMBL26153777 | 0.81 | CA2 (0.49) | MMP1MMP3MMP9CA1CA2 | |
| SCHEMBL6026266 | 0.80 | MEN1 (0.53) | CA1CA2MEN1KMT2AGAA | |
| SCHEMBL7898677 | 0.80 | MMP1 (0.51) | MMP1MMP3MMP9CA1CA2 | |
| SCHEMBL31139311 | 0.80 | CA1 (0.48) | MMP1MMP3MMP9CA1CA2 | |
| SCHEMBL23998665 | 0.79 | CTSS (0.51) | CA2MEN1KMT2AGAAATM | |
| SCHEMBL23106074 | 0.79 | CTSK (0.50) | CA2MEN1KMT2AGAACTSS | |
| SCHEMBL14509569 | 0.79 | MEN1 (0.46) | CA1CA2MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210205463-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2021-07-08 | — | — | US | disclosed |
| US-10967068-B2 | Stability-modulating linkers for use with antibody drug conjugates | PFIZER INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-20180140714-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10967068-B2 | Stability-modulating linkers for use with antibody drug conjugates | FCGR2A, FCGRT, FCGR1A | MMP1 4159/4885MMP3 3528/4885MMP9 2318/4885 |
| US-20210205463-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | FCGR2A, FCGRT, FCGR1A | MMP1 4159/4885MMP3 3528/4885MMP9 2318/4885 |
| US-20180140714-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | FCGR2A, FCGRT, FCGR1A | MMP1 4159/4885MMP3 3528/4885MMP9 2318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.