Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 9/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018088 | 0.79 | TNF (0.53) | ACSS2KCNH2SMN1; SMN2TNFTSHR | |
| SCHEMBL2020767 | 0.75 | ACSS2 (0.54) | ACSS2KCNH2SMN1; SMN2TNFTSHR | |
| SCHEMBL2013679 | 0.75 | PPARG (0.45) | ACSS2TNFTSHRKDM4EPOLB | |
| SCHEMBL2020612 | 0.72 | ACSS2 (0.56) | ACSS2KCNH2SMN1; SMN2POLBKMT2A | |
| SCHEMBL2015276 | 0.71 | PPARG (0.49) | ACSS2TNFTSHRKDM4EPOLB | |
| SCHEMBL2017366 | 0.70 | POLB (0.64) | SMN1; SMN2TNFTSHRKDM4EPOLB | |
| SCHEMBL12634882 | 0.69 | KDM4E (0.34) | SMN1; SMN2KDM4EMEN1KMT2AHTT | |
| SCHEMBL2015354 | 0.68 | PPARG (0.52) | ACSS2SMN1; SMN2TSHRKDM4EMEN1 | |
| SCHEMBL2019390 | 0.68 | BACE1 (0.41) | ACSS2TNFTSHRKDM4E | |
| SCHEMBL2014360 | 0.66 | PPARG (0.45) | TNFTSHRKDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |