Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17180545 | 0.90 | TAAR1 (0.38) | IDH1CYP3A4TSHR | |
| SCHEMBL9139369 | 0.83 | TP53 (0.41) | CALM1IDH1BCL2BCL2L1LTA4H | |
| SCHEMBL11858006 | 0.83 | NOS3 (0.38) | KDM4EMAPT | |
| SCHEMBL5050246 | 0.81 | — | — | |
| SCHEMBL7463268 | 0.76 | CALM1 (0.44) | CALM1BCL2BCL2L1LTA4HCYP3A4 | |
| SCHEMBL8433112 | 0.74 | L3MBTL1 (0.37) | CALM1IDH1BCL2BCL2L1CYP3A4 | |
| SCHEMBL339444 | 0.74 | HTR1D (0.38) | — | |
| SCHEMBL2852601 | 0.73 | CALM1 (0.41) | CALM1IDH1BCL2BCL2L1LTA4H | |
| SCHEMBL18138382 | 0.73 | CYP2C19 (0.49) | IDH1CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL2091627 | 0.73 | CALM1 (0.57) | CALM1IDH1BCL2BCL2L1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091945-B1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2014-01-15 | — | — | EP | claimed |
| US-8871877-B2 | Hybrid organic-inorganic materials that contain stabilized carbene | UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL) (FR) | 2014-10-28 | — | — | US | disclosed |
| EP-2091945-B1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2014-01-15 | — | — | EP | disclosed |
| US-8420684-B2 | imidazole derivatives; Alzheimer's Disease, Down syndrome, Huntington's Disease; hypotensive agents; sleeping/eating disorders, anxiolytic agents, antidepressants, antiepileptic agents; drug abuse/withdrawl; 4-Cyclopropylimino-5-(3,4-dihydro-2H-pyran-2-yl)-1-(3-imidazol-1-yl-propyl)-imidazolidin-2-one | PROBIODRUG AG (DE) | 2013-04-16 | — | — | US | disclosed |
| US-20110160412-A1 | HYBRID ORGANIC-INORGANIC MATERIALS THAT CONTAIN STABILIZED CARBENE | UNIVERSITE CLAUDE BERNARD LYON | 2011-06-30 | — | — | US | disclosed |
| EP-2091945-A1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009092814-A1 | HYBRID ORGANIC-INORGANIC MATERIALS THAT CONTAIN STABILIZED CARBENE | CPE LYON FORMATION CONTINUE ET RECHERCHE (FR) | 2009-07-30 | — | — | WO | disclosed |
| US-20080221086-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2008-09-11 | — | — | US | disclosed |
| WO-2008055947-A1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160412-A1 | HYBRID ORGANIC-INORGANIC MATERIALS THAT CONTAIN STABILIZED CARBENE | VIM, OSTC, ORC3 | CALM1 2217/4885IDH1 27/4885BCL2 4343/4885 |
| US-20080221086-A1 | Novel Inhibitors of Glutaminyl Cyclase | GLS, GLS2, GLUL | CALM1 3253/4885IDH1 40/4885BCL2 4725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.