Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363368 | 0.80 | TRPA1 (0.42) | HSD17B1BACE1MEN1KMT2AALDH1A1 | |
| SCHEMBL20428093 | 0.78 | AXL (0.33) | BACE1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL19829805 | 0.76 | EGFR (0.32) | BACE1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL7932090 | 0.76 | HSD17B1 (0.37) | HSD17B1BACE1KMT2AHTTMAPT | |
| SCHEMBL23864738 | 0.75 | HPGD (0.34) | MEN1KMT2AALDH1A1HTT | |
| SCHEMBL23864469 | 0.72 | HPGD (0.34) | MEN1KMT2AALDH1A1HTT | |
| SCHEMBL8460949 | 0.72 | HSD17B1 (0.37) | HSD17B1ALDH1A1 | |
| SCHEMBL20262941 | 0.71 | HSD17B1 (0.41) | HSD17B1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL29483331 | 0.71 | HSD17B1 (0.41) | HSD17B1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL18508977 | 0.71 | NR1H4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327013-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | Celgene Corporation (US) | 2018-05-30 | — | — | EP | disclosed |