SCHEMBL20195641

SCHEMBL20195641

CCOc1cccc(C(=O)Cl)c1COc1cccnc1C

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.43
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
HTT P42858 1/20 0.42
RXFP1 Q9HBX9 3/20 0.40
L3MBTL1 Q9Y468 4/20 0.40
SGMS2 Q8NHU3 2/20 0.40
ALDH1A1 P00352 1/20 0.40
ATM Q13315 1/20 0.40
MAPK1 P28482 1/20 0.39
PPIA P62937 1/20 0.38
MAPT P10636 1/20 0.38
HCRTR1 O43613 1/20 0.38
DCPS Q96C86 1/20 0.38
KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20195587 0.89 P2RX7 (0.43) P2RX7KMT2AMEN1SGMS2DCPS
SCHEMBL20195605 0.86 SGMS2 (0.48) P2RX7KMT2AHTTL3MBTL1SGMS2
SCHEMBL20195552 0.85 ALDH1A1 (0.43) KMT2AMEN1HTTRXFP1L3MBTL1
SCHEMBL20195631 0.81 SSTR4 (0.41) P2RX7KMT2ASGMS2DCPS
SCHEMBL20195640 0.79 TP53 (0.42) KMT2AMEN1RXFP1L3MBTL1MAPT
SCHEMBL20195660 0.78 ALDH1A1 (0.51) KMT2AMEN1HTTL3MBTL1ALDH1A1
SCHEMBL31461865 0.76 ALDH1A1 (0.52) KMT2AMEN1HTTL3MBTL1ALDH1A1
SCHEMBL8325639 0.76 ALDH1A1 (0.52) KMT2AMEN1HTTL3MBTL1ALDH1A1
SCHEMBL18504683 0.75 KDM4E (0.38) KMT2AMEN1HTTRXFP1L3MBTL1
SCHEMBL20195598 0.74 KMT2A (0.49) KMT2AMEN1HTTRXFP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3029035-B1 TETRAZOLINONE COMPOUND, AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2018-05-30 EP disclosed