Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20197271 | 0.88 | MEN1 (0.39) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL20197228 | 0.86 | CYP1A1 (0.42) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL16535109 | 0.83 | MEN1 (0.51) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL20197302 | 0.82 | SMN1; SMN2 (0.46) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL20197243 | 0.78 | NUDT1 (0.45) | — | |
| SCHEMBL20197318 | 0.76 | EIF4E (0.46) | SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL20197303 | 0.75 | CYP1A2 (0.32) | SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL19059522 | 0.74 | MEN1 (0.78) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL20197336 | 0.74 | CYP19A1 (0.46) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL20197472 | 0.73 | CYP1B1 (0.36) | MEN1KMT2AMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |