SCHEMBL20206327

SCHEMBL20206327

CC(=O)NCC(=O)N[C@H]1CNC(=O)CCC(=O)NCC[C@@H](C(=O)NCC(N)=O)NC(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 4/20 0.39
▸ MC1R Q01726 4/20 0.39
▸ TSLP Q969D9 2/20 0.38
▸ OPRM1 P35372 1/20 0.37
▸ OPRD1 P41143 1/20 0.37
▸ OPRK1 P41145 1/20 0.37
▸ CTSG P08311 1/20 0.35
▸ TACR2 P21452 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20362936 0.96 TSLP (0.39) MC4RMC1RTSLPOPRM1OPRD1
SCHEMBL22606361 0.95 MC4R (0.39) MC4RMC1RTSLPOPRM1OPRD1
SCHEMBL20206173 0.95 TSLP (0.39) MC4RMC1RTSLPOPRM1OPRD1
SCHEMBL20362939 0.95 TSLP (0.39) MC4RMC1RTSLPOPRM1OPRD1
SCHEMBL22606167 0.92 TSLP (0.39) TSLPCTSGTACR2
SCHEMBL20363003 0.91 MC4R (0.40) MC4RMC1RTSLP
SCHEMBL20206167 0.91 FCGRT (0.39) MC4RMC1RTSLP
SCHEMBL20206196 0.90 TUBB4A (0.38) MC4RMC1RTSLPOPRM1OPRD1
SCHEMBL20362935 0.89 TSLP (0.37) MC1RTSLPOPRM1OPRD1OPRK1
SCHEMBL20206237 0.88 TACR2 (0.42) MC4RMC1RTSLPOPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11286280-B2 Melanocortin-1 receptor-specific peptides for cytokine storm and inflammation therapy PALATIN TECHNOLOGIES, INC. (US) 2022-03-29 — — US disclosed
US-20200339631-A1 Melanocortin-1 Receptor-Specific Peptides for Cytokine Storm and Inflammation Therapy PALATIN TECHNOLOGIES INC (US) 2020-10-29 — — US disclosed
US-10711039-B2 Melanocortin receptor-specific peptide with C-terminal naphthylalanine PALATIN TECHNOLOGIES, INC. (US) 2020-07-14 — — US disclosed
US-10017539-B2 Melanocortin-1 receptor-specific cyclic hexapeptides PALATIN TECHNOLOGIES, INC. (US) 2018-07-10 — — US disclosed
US-20180148478-A1 Melanocortin Receptor-Specific Peptide with C-Terminal Naphthylalanine PALATIN TECHNOLOGIES INC (US) 2018-05-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10711039-B2 Melanocortin receptor-specific peptide with C-terminal naphthylalanine MC1R, MC3R, MC4R MC4R 3/4885MC1R 1/4885TSLP 624/4885
US-11286280-B2 Melanocortin-1 receptor-specific peptides for cytokine storm and inflammation therapy MC3R, MC1R, MC2R MC4R 6/4885MC1R 2/4885TSLP 15/4885
US-10017539-B2 Melanocortin-1 receptor-specific cyclic hexapeptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885TSLP 357/4885
US-20200339631-A1 Melanocortin-1 Receptor-Specific Peptides for Cytokine Storm and Inflammation Therapy MC3R, MC1R, MC2R MC4R 6/4885MC1R 2/4885TSLP 15/4885
US-20180148478-A1 Melanocortin Receptor-Specific Peptide with C-Terminal Naphthylalanine MC1R, MC3R, MC4R MC4R 3/4885MC1R 1/4885TSLP 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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