Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.52 |
| ▸ | PRKACA | P17612 | 2/20 | 0.52 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | PRKX | P51817 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217342 | 0.91 | APLNR (0.49) | TACR3APLNR | |
| SCHEMBL20217243 | 0.88 | KDM4E (0.51) | TACR3KDM4E | |
| SCHEMBL20217534 | 0.87 | ROCK1 (0.48) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL20217347 | 0.86 | ALDH1A1 (0.47) | ROCK1GSK3AGSK3BCLK4PRKCQ | |
| SCHEMBL20217203 | 0.85 | TAS1R3 (0.59) | ROCK1ROCK2TACR3TAS1R3TAS1R1 | |
| SCHEMBL10324549 | 0.79 | ROCK1 (0.56) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL10324548 | 0.77 | ROCK1 (0.54) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL20217729 | 0.77 | F10 (0.44) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL20217304 | 0.77 | F10 (0.44) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL20217176 | 0.76 | ROCK2 (0.50) | ROCK1PRKACAGSK3AGSK3BPRKX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |