Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 10/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217320 | 0.87 | KCNK3 (0.44) | CTSAKCNK3 | |
| SCHEMBL20217148 | 0.85 | GRN (0.43) | CTSAROCK2 | |
| SCHEMBL20217174 | 0.85 | GRN (0.43) | CTSAROCK2 | |
| SCHEMBL20217493 | 0.82 | CTSA (0.39) | CTSA | |
| SCHEMBL20217242 | 0.81 | AKT1 (0.41) | KMT2AF10ROCK2 | |
| SCHEMBL20217886 | 0.78 | F10 (0.38) | CTSAKCNK3F10JAK2PRSS1 | |
| SCHEMBL20217243 | 0.73 | KDM4E (0.51) | — | |
| SCHEMBL20217347 | 0.72 | ALDH1A1 (0.47) | ROCK2 | |
| SCHEMBL20217138 | 0.72 | ROCK1 (0.52) | ROCK2 | |
| SCHEMBL20217342 | 0.72 | APLNR (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |