Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.35 |
| ▸ | MERTK | Q12866 | 4/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219430 | 0.85 | TLR7 (0.42) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL15470024 | 0.84 | TLR7 (0.51) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL20219350 | 0.81 | ALDH1A1 (0.32) | TLR7TLR8ALDH1A1 | |
| SCHEMBL20219322 | 0.80 | CYP1A2 (0.42) | TLR7TLR8ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL23472560 | 0.80 | CYP3A4 (0.46) | TLR7TLR8KDM4EALDH1A1HPGD | |
| SCHEMBL23472434 | 0.79 | CYP2D6 (0.40) | TLR7TLR8KDM4EALDH1A1CYP1A2 | |
| SCHEMBL23472425 | 0.79 | CASP6 (0.41) | TLR7TLR8KDM4ECYP1A2CYP2D6 | |
| SCHEMBL23472511 | 0.78 | CHRNB2 (0.43) | TLR7TLR8CYP1A2CYP2D6TYRO3 | |
| SCHEMBL20219702 | 0.77 | ALDH1A1 (0.35) | TLR7TLR8ALDH1A1L3MBTL1 | |
| SCHEMBL23472593 | 0.77 | CYP1A2 (0.43) | TLR7TLR8ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |