Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.36 |
| ▸ | RELA | Q04206 | 5/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882850 | 0.75 | MAPK1 (0.40) | MAPK1NFKB1NFKB2RELARECQL | |
| SCHEMBL13947270 | 0.73 | MAPK1 (0.39) | MAPK1NFKB1NFKB2RELARECQL | |
| SCHEMBL18901801 | 0.67 | NFKB1 (0.40) | NFKB1NFKB2RELA | |
| SCHEMBL11438423 | 0.67 | MAPK1 (0.39) | MAPK1NFKB1NFKB2RELA | |
| SCHEMBL23007075 | 0.66 | NFKB1 (0.38) | MAPK1NFKB1NFKB2RELARECQL | |
| SCHEMBL15414408 | 0.64 | MAPK1 (0.34) | MAPK1NFKB1NFKB2RELA | |
| SCHEMBL2535414 | 0.63 | MAPK1 (0.42) | MAPK1NFKB1NFKB2RELA | |
| SCHEMBL28776161 | 0.63 | NFKB1 (0.39) | MAPK1NFKB1NFKB2RELARECQL | |
| SCHEMBL21367073 | 0.62 | MAPK1 (0.33) | MAPK1 | |
| SCHEMBL7528687 | 0.62 | MAPK1 (0.38) | MAPK1NFKB1NFKB2RELARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230143552-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20180155283-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2018-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155283-A1 | DOPAMINE D2 RECEPTOR LIGANDS | DRD2, DRD3, ARRB1 | MAPK1 617/4885NFKB1 2241/4885NFKB2 1393/4885 |
| US-20230143552-A1 | DOPAMINE D2 RECEPTOR LIGANDS | DRD2, SLC6A3, NTSR2 | MAPK1 1641/4885NFKB1 2889/4885NFKB2 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.