Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.36 |
| ▸ | RELA | Q04206 | 5/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947270 | 0.92 | MAPK1 (0.39) | MAPK1NFKB1NFKB2RELAHRH3 | |
| SCHEMBL11438423 | 0.84 | MAPK1 (0.39) | MAPK1NFKB1NFKB2RELAHRH3 | |
| SCHEMBL2535414 | 0.75 | MAPK1 (0.42) | MAPK1NFKB1NFKB2RELAHRH3 | |
| SCHEMBL20224875 | 0.75 | MAPK1 (0.39) | MAPK1NFKB1NFKB2RELARECQL | |
| SCHEMBL7991378 | 0.75 | MAPK1 (0.35) | MAPK1NFKB1NFKB2RELADGAT1 | |
| SCHEMBL7718520 | 0.75 | PPM1B (0.37) | MAPK1NFKB1NFKB2RELADGAT1 | |
| SCHEMBL7999872 | 0.75 | POLB (0.46) | MAPK1NFKB1NFKB2RELAHRH3 | |
| SCHEMBL1409756 | 0.75 | ALDH1A1 (0.41) | MAPK1NFKB1NFKB2RELAHRH3 | |
| SCHEMBL15645814 | 0.75 | POLB (0.43) | MAPK1NFKB1NFKB2RELAHRH3 | |
| SCHEMBL15414408 | 0.72 | MAPK1 (0.34) | MAPK1NFKB1NFKB2RELAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040177-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA | KAREUS THERAPEUTICS, SA (CH) | 2012-03-29 | — | — | WO | disclosed |