SCHEMBL20231997

SCHEMBL20231997

CC(C)C(C(=O)O)c1cc(O)no1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
SMN1; SMN2 Q16637 10/20 0.35
ALDH1A1 P00352 3/20 0.33
HCAR2 Q8TDS4 2/20 0.32
RAB9A P51151 6/20 0.31
NPC1 O15118 4/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31
MEN1 O00255 3/20 0.31
MAPT P10636 3/20 0.31
KMT2A Q03164 3/20 0.31
LMNA P02545 2/20 0.31
HPGD P15428 2/20 0.31
TP53 P04637 1/20 0.31
HTT P42858 1/20 0.31
TSHR P16473 1/20 0.30
POLB P06746 2/20 0.30
APAF1 O14727 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30843547 1.00 AKR1C3 (0.36) AKR1C3AKR1C2SMN1; SMN2ALDH1A1HCAR2
SCHEMBL25601617 0.85 ALOX15 (0.33) SMN1; SMN2ALDH1A1RAB9ANPC1CYP1A2
SCHEMBL18551329 0.81 HCAR2 (0.48) SMN1; SMN2ALDH1A1HCAR2TSHRPOLB
SCHEMBL20294973 0.81 KMT2A (0.37) SMN1; SMN2ALDH1A1RAB9ANPC1CYP1A2
SCHEMBL30801452 0.80 ADRB2 (0.38) AKR1C3AKR1C2SMN1; SMN2ALDH1A1HCAR2
SCHEMBL20294739 0.78 THRB (0.38) SMN1; SMN2ALDH1A1RAB9ANPC1CYP1A2
SCHEMBL24102734 0.77 NOTUM (0.40) AKR1C3AKR1C2SMN1; SMN2ALDH1A1RAB9A
Ibotenic Acid SCHEMBL28147540 0.75 GRM1 (0.39) SMN1; SMN2ALDH1A1CYP1A2CYP2C19MEN1
Ibotenic Acid SCHEMBL28147541 0.75 GRM1 (0.39) SMN1; SMN2ALDH1A1CYP1A2CYP2C19MEN1
Ibotenic Acid SCHEMBL4582627 0.73 GRM1 (0.43) ALDH1A1CYP1A2CYP2C19MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115296-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES UNIV YALE (US) 2026-04-30 US disclosed
US-20260092071-A1 COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF UNIV MICHIGAN (US) 2026-04-02 US disclosed
US-12552783-B2 Modulators of proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-17 US disclosed
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS INC (US) 2026-02-12 US disclosed
US-12539292-B2 BRM targeting compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-03 US disclosed
US-20250304596-A1 PYRAZINE DERIVATIVES AND USES THEREOF FOGHORN THERAPEUTICS INC (US) 2025-10-02 US disclosed
US-20250302832-A1 PYRAZINE DERIVATIVES AND USES THEREOF FOGHORN THERAPEUTICS INC (US) 2025-10-02 US disclosed
US-20250197387-A1 BCL-XL DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-06-19 US disclosed
CN-120035593-A Pyrazine derivatives and uses thereof 福宏治疗公司 2025-05-23 CN disclosed
CN-119998278-A Compounds and uses thereof 福宏治疗公司 2025-05-13 CN disclosed
WO-2019183523-A1 HETERO-BIFUNCTIONAL DEGRADER COMPOUNDS AND THEIR USE AS MODULATORS OF TARGETED UBIQUINATION (VHL) GENENTECH, INC. (US) 2019-09-26 WO disclosed
US-20180237418-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2018-08-23 US disclosed
WO-2018140809-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas, Inc. (US) 2018-08-02 WO disclosed
WO-2018140809-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas, Inc. (US) 2018-08-02 WO disclosed
WO-2018119448-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES Arvinas, Inc. (US) 2018-06-28 WO disclosed
US-20180179183-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES ARVINAS OPERATIONS, INC. 2018-06-28 US disclosed
WO-2018119448-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES Arvinas, Inc. (US) 2018-06-28 WO disclosed
US-20180179183-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES ARVINAS OPERATIONS, INC. 2018-06-28 US disclosed
WO-2018102725-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas, Inc. (US) 2018-06-07 WO disclosed
US-20180155322-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS OPERATIONS, INC. 2018-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180179183-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES CRBN, ARAF, VHL AKR1C3 1229/4885AKR1C2 1135/4885SMN1; SMN2 2113/4885
US-12539292-B2 BRM targeting compounds and associated methods of use ADRM1, SUMO2, BAZ1A AKR1C3 3657/4885AKR1C2 3489/4885SMN1; SMN2 1205/4885
US-20250197387-A1 BCL-XL DEGRADERS AND USES THEREOF XIAP, BCL2L1, BCL2L10 AKR1C3 3115/4885AKR1C2 3180/4885SMN1; SMN2 3396/4885
US-20250302832-A1 PYRAZINE DERIVATIVES AND USES THEREOF BRCA1, VHL, SF3B5 AKR1C3 2720/4885AKR1C2 2256/4885SMN1; SMN2 784/4885
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, VHL, BAZ1A AKR1C3 3045/4885AKR1C2 3195/4885SMN1; SMN2 1134/4885
US-12552783-B2 Modulators of proteolysis and associated methods of use CRBN, ADRM1, MDM2 AKR1C3 2874/4885AKR1C2 3082/4885SMN1; SMN2 903/4885
US-20180155322-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS MDM2, CRBN, VHL AKR1C3 1992/4885AKR1C2 2066/4885SMN1; SMN2 2139/4885
US-20250304596-A1 PYRAZINE DERIVATIVES AND USES THEREOF VHL, BRCA1, SF3B5 AKR1C3 3101/4885AKR1C2 2606/4885SMN1; SMN2 1047/4885
US-20180237418-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE ADRM1, MDM2, ESR2 AKR1C3 1942/4885AKR1C2 2047/4885SMN1; SMN2 1543/4885
US-20260115296-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES CRBN, VHL, ADRM1 AKR1C3 1729/4885AKR1C2 1869/4885SMN1; SMN2 2142/4885
US-20260092071-A1 COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF SMARCC2, SMARCC1, SMARCA2 AKR1C3 110/4885AKR1C2 113/4885SMN1; SMN2 79/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.