Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 4/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.45 |
| ▸ | LOX | P28300 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20259233 | 0.91 | LOX (0.45) | VNN1LOXL2LOXCYP3A4CYP1A2 | |
| SCHEMBL18249766 | 0.81 | PLAAT3 (0.44) | VNN1LOXL2LOXMAP2K7 | |
| SCHEMBL20259265 | 0.78 | ACACB (0.55) | — | |
| SCHEMBL20239268 | 0.78 | ACACB (0.48) | LOXL2 | |
| SCHEMBL20239301 | 0.78 | LMNA (0.41) | VNN1LOXL2LOXCYP3A4SMN1; SMN2 | |
| SCHEMBL20239191 | 0.78 | LOXL2 (0.44) | VNN1LOXL2LOX | |
| SCHEMBL20239181 | 0.77 | ALDH1A1 (0.45) | VNN1CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20239188 | 0.77 | DGAT2 (0.40) | VNN1LOXL2LOX | |
| Hydrochloric Acid SCHEMBL21924527 | 0.76 | LOXL2 (0.40) | VNN1LOXL2LOX | |
| Hydrochloric Acid SCHEMBL21924528 | 0.76 | LOXL2 (0.40) | VNN1LOXL2LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | VNN1 3148/4885LOXL2 2081/4885LOX 2453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.