Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.32 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.32 |
| ▸ | PPP5C | P53041 | 1/20 | 0.32 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16174694 | 0.70 | PTPN1 (0.33) | TSHRLMNAPTPN1KDM4E | |
| SCHEMBL3091285 | 0.67 | GLA (0.41) | MAPT | |
| SCHEMBL21961915 | 0.65 | CTSD (0.32) | TSHRLMNA | |
| SCHEMBL13758455 | 0.65 | — | — | |
| SCHEMBL3715467 | 0.64 | ALDH1A1 (0.36) | TSHRL3MBTL1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL12669329 | 0.64 | — | — | |
| SCHEMBL1562353 | 0.63 | TSHR (0.38) | TSHRPOLBL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL892475 | 0.62 | TSHR (0.39) | TSHRPOLBL3MBTL1TP53CYP3A4 | |
| SCHEMBL16768500 | 0.62 | TSHR (0.35) | TSHRPOLBL3MBTL1TP53CYP3A4 | |
| SCHEMBL15960847 | 0.62 | TSHR (0.36) | TSHRPOLBL3MBTL1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12180211-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2024-12-31 | — | — | US | disclosed |
| EP-3552017-B1 | COMPOUNDS USEFUL AS RIPK1 INHIBITORS | DENALI THERAPEUTICS INC (US) | 2022-02-23 | — | — | EP | disclosed |
| US-20210332058-A1 | Compounds, Compositions and Methods | DENALI THERAPEUTICS INC. (US) | 2021-10-28 | — | — | US | disclosed |
| US-11072618-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2021-07-27 | — | — | US | disclosed |
| EP-3552017-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2019-10-16 | — | — | EP | disclosed |
| US-20190300537-A1 | Compounds, Compositions and Methods | DENALI THERAPEUTICS INC. (US) | 2019-10-03 | — | — | US | disclosed |
| WO-2018107060-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2018-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12180211-B2 | Compounds, compositions and methods | BAX, CASP3, CASP8 | TSHR 4796/4885POLB 918/4885L3MBTL1 657/4885 |
| US-11072618-B2 | Compounds, compositions and methods | BAX, CASP3, CASP8 | TSHR 4796/4885POLB 918/4885L3MBTL1 657/4885 |
| US-20210332058-A1 | Compounds, Compositions and Methods | BAX, CASP3, CASP8 | TSHR 4796/4885POLB 918/4885L3MBTL1 657/4885 |
| US-20190300537-A1 | Compounds, Compositions and Methods | BAX, CASP3, CASP8 | TSHR 4796/4885POLB 918/4885L3MBTL1 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.