Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29575721 | 1.00 | NR4A2 (0.47) | NR4A2CREBBPMAP2K1KDM4ESMN1; SMN2 | |
| SCHEMBL16549389 | 0.87 | KDM4E (0.56) | KDM4EPDK2ALDH1A1MAPTTSHR | |
| SCHEMBL3302698 | 0.85 | TAS2R14 (0.47) | KDM4EALDH1A1HPGDTAS2R14 | |
| SCHEMBL29410865 | 0.85 | TAS2R14 (0.47) | KDM4EALDH1A1HPGDTAS2R14 | |
| SCHEMBL30889359 | 0.84 | KDM4E (0.45) | KDM4EPDK2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL31407282 | 0.84 | PARP1 (0.46) | KDM4ESMN1; SMN2ALDH1A1HPGDTAS2R14 | |
| SCHEMBL2359095 | 0.84 | NR4A2 (0.41) | NR4A2CREBBPMAP2K1CFTRPDK2 | |
| SCHEMBL23275797 | 0.83 | KDM4E (0.44) | KDM4ESMN1; SMN2SLC6A3ALDH1A1CYP3A4 | |
| SCHEMBL29410845 | 0.83 | KDM4E (0.44) | KDM4ESMN1; SMN2SLC6A3ALDH1A1CYP3A4 | |
| SCHEMBL2359646 | 0.83 | NR4A2 (0.51) | NR4A2MAP2K1SMN1; SMN2CFTRPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456098-B | Preparation method of medicine Ai Shali ketone for treating diabetic nephropathy | 大连理工大学 | 2024-06-14 | — | — | CN | claimed |
| CN-114456098-A | Preparation method of diabetic nephropathy medicine namely elsamiloride | 大连理工大学 | 2022-05-10 | — | — | CN | claimed |
| US-20240239746-A1 | PREPARATION METHOD FOR PYRROLE AMIDE COMPOUND | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2024-07-18 | — | — | US | disclosed |
| CN-114456098-B | Preparation method of medicine Ai Shali ketone for treating diabetic nephropathy | 大连理工大学 | 2024-06-14 | — | — | CN | disclosed |
| CN-114456098-A | Preparation method of diabetic nephropathy medicine namely elsamiloride | 大连理工大学 | 2022-05-10 | — | — | CN | disclosed |
| EP-1773768-B1 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2018-08-22 | — | — | EP | disclosed |
| EP-1844020-B1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS | EXELIXIS INC (US) | 2017-09-06 | — | — | EP | disclosed |
| US-8754118-B2 | Atropisomer of pyrrole derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-06-17 | — | — | US | disclosed |
| US-20140024696-A1 | ATROPISOMER OF PYRROLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-01-23 | — | — | US | disclosed |
| CN-101006052-B | Pyrrole derivatives as pharmaceutical agents | EXELIXIS INC | 2013-11-06 | — | — | CN | disclosed |
| US-8524918-B2 | Atropisomer of pyrrole derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-09-03 | — | — | US | disclosed |
| US-20100093826-A1 | ATROPISOMER OF PYRROLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| CN-101679243-A | atropisomer of pyrrole derivative | DAIICHI SANKYO CO | 2010-03-24 | — | — | CN | disclosed |
| EP-2133330-A1 | ATROPISOMER OF PYRROLE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-12-16 | — | — | EP | disclosed |
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1844020-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTOR LIGANDS | Exelixis, Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006076202-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS AS STEROID NUCLEAR RECEPTORS LIGANDS | EXELIXIS, INC. (US) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | PRLHR, PTGDR, TACR1 | NR4A2 416/4885CREBBP 699/4885MAP2K1 4660/4885 |
| US-20140024696-A1 | ATROPISOMER OF PYRROLE DERIVATIVE | CYP11B2, CYP11B1, PYCR1 | NR4A2 1988/4885CREBBP 3080/4885MAP2K1 4624/4885 |
| US-20100093826-A1 | ATROPISOMER OF PYRROLE DERIVATIVE | CYP11B2, CYP11B1, PYCR1 | NR4A2 1988/4885CREBBP 3080/4885MAP2K1 4624/4885 |
| US-20240239746-A1 | PREPARATION METHOD FOR PYRROLE AMIDE COMPOUND | HPGDS, HRH4, FAAH | NR4A2 3207/4885CREBBP 1819/4885MAP2K1 2846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.