Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248922 | 0.84 | ALDH1A1 (0.49) | ALDH1A1ACHEMAPTKMT2AMEN1 | |
| SCHEMBL29862307 | 0.83 | PARK7 (0.68) | ALDH1A1ACHEPARK7MAPTKMT2A | |
| SCHEMBL396957 | 0.83 | PARK7 (0.68) | ALDH1A1ACHEPARK7MAPTKMT2A | |
| SCHEMBL20248930 | 0.82 | PARK7 (0.71) | ALDH1A1PARK7 | |
| SCHEMBL16521837 | 0.80 | ACHE (0.56) | ALDH1A1ACHEMAPTKMT2AMEN1 | |
| SCHEMBL14867085 | 0.77 | ACHE (0.44) | ALDH1A1ACHEMAPTKMT2AMEN1 | |
| SCHEMBL13546141 | 0.73 | ALDH1A1 (0.65) | ALDH1A1ACHEMAPTKMT2AMEN1 | |
| SCHEMBL20248919 | 0.73 | ACHE (0.44) | ALDH1A1ACHEMAPTKMT2AMEN1 | |
| SCHEMBL16048726 | 0.72 | ALDH1A1 (0.60) | ALDH1A1ACHEMAPTKMT2AMEN1 | |
| SCHEMBL4625552 | 0.71 | ALDH1A1 (0.62) | ALDH1A1ACHEMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162867-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162867-A1 | EIS INHIBITORS | EP300, ACAT1, ACAT2 | ALDH1A1 1232/4885ACHE 892/4885PARK7 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.