Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24294068 | 0.94 | KCNH2 (0.52) | KCNH2ALDH1A1MAPTMGLLLOXL2 | |
| SCHEMBL22623273 | 0.91 | KCNH2 (0.50) | KCNH2ALDH1A1MAPTMGLLLOXL2 | |
| SCHEMBL8094802 | 0.90 | KCNH2 (0.49) | KCNH2ALDH1A1MAPTMGLLLOXL2 | |
| Hydrochloric Acid SCHEMBL392352 | 0.87 | KCNH2 (0.47) | KCNH2ALDH1A1MAPTMGLLLOXL2 | |
| SCHEMBL8087727 | 0.85 | BDKRB2 (0.50) | KCNH2ALDH1A1MAPTMGLLL3MBTL1 | |
| SCHEMBL18071831 | 0.84 | LOXL2 (0.52) | KCNH2ALDH1A1MAPTLOXL2CYP2C19 | |
| SCHEMBL9710521 | 0.82 | KCNH2 (0.50) | KCNH2ALDH1A1MAPTMGLLLOXL2 | |
| SCHEMBL29199056 | 0.82 | KCNH2 (0.50) | KCNH2ALDH1A1MAPTMGLLLOXL2 | |
| SCHEMBL28807880 | 0.79 | ALDH1A1 (0.49) | KCNH2ALDH1A1MGLLPOLBMEN1 | |
| SCHEMBL8815113 | 0.78 | KCNH2 (0.49) | KCNH2ALDH1A1MAPTMGLLLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162854-A1 | Inhibitors of Leukotriene A4 Hydrolase | CELLTAXIS, LLC | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162854-A1 | Inhibitors of Leukotriene A4 Hydrolase | LTA4H, LTC4S, LTB4R | KCNH2 2654/4885ALDH1A1 490/4885MAPT 4534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.