Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL202539 | 0.80 | LMNA (0.52) | TSHRLMNAF2ALDH1A1CYP1A2 | |
| SCHEMBL2687353 | 0.78 | ALDH1A1 (0.50) | TSHRLMNAF2ALDH1A1ADRB2 | |
| SCHEMBL10910774 | 0.76 | TSHR (0.46) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL1759366 | 0.75 | TSHR (0.58) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL7070049 | 0.75 | TSHR (0.58) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL203317 | 0.75 | TSHR (0.58) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL9487455 | 0.74 | TSHR (0.41) | TSHRLMNAF2ALDH1A1ADRB2 | |
| SCHEMBL21603078 | 0.74 | TSHR (0.52) | TSHRLMNAF2ALDH1A1ADRB2 | |
| SCHEMBL28346238 | 0.72 | TSHR (0.54) | TSHRLMNAF2ALDH1A1TDP1 | |
| SCHEMBL10733991 | 0.71 | LMNA (0.61) | TSHRLMNAF2ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088872-B2 | Procatalyst composition including silyl ester internal donor and method | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-01-03 | — | — | US | claimed |
| US-20100130709-A1 | Procatalyst Composition Including Silyl Ester Internal Donor and Method | W. R. GRACE & CO.-CONN. | 2010-05-27 | — | — | US | claimed |
| EP-2350143-B1 | PROCATALYST COMPOSITION MULTIPLE INTERNAL DONOR HAVING SILYL ESTER AND METHOD | GRACE W R & CO (US) | 2016-02-17 | — | — | EP | disclosed |
| EP-2350144-B1 | PROCATALYST COMPOSITION INCLUDING SILYL ESTER INTERNAL DONOR AND METHOD | GRACE W R & CO (US) | 2015-07-15 | — | — | EP | disclosed |
| US-8222357-B2 | Procatalyst composition with multiple internal donor having silyl ester and method | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC (US) | 2012-07-17 | — | — | US | disclosed |
| US-8088872-B2 | Procatalyst composition including silyl ester internal donor and method | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2350144-A1 | PROCATALYST COMPOSITION INCLUDING SILYL ESTER INTERNAL DONOR AND METHOD | Dow Global Technologies LLC (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010065361-A1 | PROCATALYST COMPOSITION INCLUDING SILYL ESTER INTERNAL DONOR AND METHOD | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20100130710-A1 | Procatalyst Composition with Multiple Internal Donor Having Silyl Ester and Method | W. R. GRACE & CO.-CONN. | 2010-05-27 | — | — | US | disclosed |
| US-20100130709-A1 | Procatalyst Composition Including Silyl Ester Internal Donor and Method | W. R. GRACE & CO.-CONN. | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130709-A1 | Procatalyst Composition Including Silyl Ester Internal Donor and Method | GNE, NANS, ELANE | TSHR 4670/4885LMNA 1109/4885F2 547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.