Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfotep. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.45 |
| ▸ | PPARG | P37231 | 7/20 | 0.45 |
| ▸ | PPARD | Q03181 | 7/20 | 0.45 |
| ▸ | PPARA | Q07869 | 7/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.45 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfotep SCHEMBL2336663 | 0.98 | GPR84 (0.48) | AKR1B1GPR84PPARGPPARDPPARA | |
| Sulfotep SCHEMBL2786434 | 0.98 | GPR84 (0.48) | AKR1B1GPR84PPARGPPARDPPARA | |
| Sulfotep SCHEMBL1163364 | 0.94 | AKR1B1 (0.57) | AKR1B1GPR84PPARGPPARDPPARA | |
| Sulfotep SCHEMBL8472533 | 0.93 | GPR84 (0.59) | AKR1B1GPR84PPARGPPARDPPARA | |
| Sulfotep SCHEMBL1163969 | 0.92 | AKR1B1 (0.48) | AKR1B1GPR84PPARGPPARDPPARA | |
| Sulfotep SCHEMBL1163295 | 0.88 | FFAR3 (0.52) | AKR1B1GPR84PPARGPPARDPPARA | |
| Sulfotep SCHEMBL7767701 | 0.88 | FFAR3 (0.52) | AKR1B1GPR84PPARGPPARDPPARA | |
| Sulfotep SCHEMBL1163901 | 0.85 | FFAR3 (0.46) | PPARDTSHRALDH1A1TDP1KMT2A | |
| Sulfotep SCHEMBL7762968 | 0.85 | FFAR3 (0.46) | PPARDTSHRALDH1A1TDP1KMT2A | |
| Sulfotep SCHEMBL461502 | 0.85 | TDP1 (0.39) | PPARDTSHRALDH1A1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304468-B2 | Polymers comprising thioester bonds | DSM IP ASSETS B.V. (NL) | 2012-11-06 | — | — | US | claimed |
| US-20090156707-A1 | Polymers comprising thioester bonds | DSM IP ASSETS B.V. (NL) | 2009-06-18 | — | — | US | claimed |
| EP-1922351-A1 | POLYMERS COMPRISING THIOESTER BONDS | DSMIP Assets B.V. (NL) | 2008-05-21 | — | — | EP | claimed |
| WO-2007028612-A1 | POLYMERS COMPRISING THIOESTER BONDS | DSM IP ASSETS B.V. (NL) | 2007-03-15 | — | — | WO | claimed |
| CN-106459687-A | Adhesive sheet and optical member | 日东电工株式会社 | 2017-02-22 | — | — | CN | disclosed |
| CN-106255733-A | Adhesive sheet and optics | 日东电工株式会社 | 2016-12-21 | — | — | CN | disclosed |
| CN-106232755-A | Adhesive sheet and optical member | 日东电工株式会社 | 2016-12-14 | — | — | CN | disclosed |
| CN-105733461-A | Adhesive sheet and optical member | 日东电工株式会社 | 2016-07-06 | — | — | CN | disclosed |
| CN-105733459-A | Adhesive sheet and optical member | 日东电工株式会社 | 2016-07-06 | — | — | CN | disclosed |
| CN-105733460-A | Adhesive sheet and optical member | 日东电工株式会社 | 2016-07-06 | — | — | CN | disclosed |
| US-8304468-B2 | Polymers comprising thioester bonds | DSM IP ASSETS B.V. (NL) | 2012-11-06 | — | — | US | disclosed |
| US-20110301288-A1 | THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS | DSM IP ASSETS B.V. (NL) | 2011-12-08 | — | — | US | disclosed |
| CN-102014879-A | Particles comprising polymers with thioester bonds | DSM IP ASSETS BV | 2011-04-13 | — | — | CN | disclosed |
| EP-2265262-A1 | PARTICLES COMPRISING POLYMERS WITH THIOESTER BONDS | DSM IP Assets B.V. (NL) | 2010-12-29 | — | — | EP | disclosed |
| WO-2010070132-A1 | THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS | DSM IP ASSETS B.V. (NL) | 2010-06-24 | — | — | WO | disclosed |
| EP-2199281-A1 | Thioic acids as building block for polythioesters | DSM IP Assets B.V. (NL) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009130332-A1 | PARTICLES COMPRISING POLYMERS WITH THIOESTER BONDS | DSM IP ASSETS B.V. (NL) | 2009-10-29 | — | — | WO | disclosed |
| US-20090156707-A1 | Polymers comprising thioester bonds | DSM IP ASSETS B.V. (NL) | 2009-06-18 | — | — | US | disclosed |
| EP-1922351-A1 | POLYMERS COMPRISING THIOESTER BONDS | DSMIP Assets B.V. (NL) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007028612-A1 | POLYMERS COMPRISING THIOESTER BONDS | DSM IP ASSETS B.V. (NL) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301288-A1 | THIOIC ACIDS AS BUILDING BLOCK FOR POLYTHIOESTERS | OXER1, OXGR1, HPD | AKR1B1 414/4885GPR84 2096/4885PPARG 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.