Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22016779 | 0.82 | KDM4E (0.40) | CRHR1LMNAADORA3NOX4KDM5B | |
| SCHEMBL21921254 | 0.78 | ATAD2 (0.36) | LMNAADORA3NOX4KDM5BKDM4E | |
| SCHEMBL23961767 | 0.78 | GABRA1 (0.45) | CRHR1ALDH1A1GAA | |
| SCHEMBL17471276 | 0.78 | ALDH1A1 (0.39) | CRHR1LMNAADORA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL22016469 | 0.76 | PDE3B (0.45) | CRHR1L3MBTL1KMT2APDE3BPDE3A | |
| SCHEMBL14803746 | 0.74 | ITGB1 (0.36) | LMNAADORA3KDM5BKDM4EALDH1A1 | |
| SCHEMBL22016206 | 0.72 | BRPF1 (0.34) | LMNAADORA3KDM5BL3MBTL1KMT2A | |
| SCHEMBL12009459 | 0.72 | MAPT (0.34) | CRHR1LMNAKDM4EKMT2AALDH1A1 | |
| SCHEMBL12180267 | 0.71 | LMNA (0.34) | CRHR1LMNAADORA3KDM4EL3MBTL1 | |
| SCHEMBL18999990 | 0.70 | CRHR1 (0.33) | CRHR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550071-B2 | PPAR agonists | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2020-02-04 | — | — | US | disclosed |
| US-20180170857-A1 | PPAR AGONISTS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170857-A1 | PPAR AGONISTS | PPARG, PPARD, PPARA | CRHR1 3470/4885LMNA 1003/4885ADORA3 1016/4885 |
| US-10550071-B2 | PPAR agonists | PPARG, PPARD, PPARA | CRHR1 3470/4885LMNA 1003/4885ADORA3 1016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.