Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 10/20 | 0.39 |
| ▸ | GABRD | O14764 | 10/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 10/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 10/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 10/20 | 0.39 |
| ▸ | GABRE | P78334 | 10/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 10/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 10/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 10/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 10/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19655773 | 1.00 | GRIN1 (0.42) | GRIN1GRIN2BGABRPGABRDGABRA1 | |
| SCHEMBL22072807 | 0.82 | GRIN1 (0.42) | GRIN1GRIN2BGABRPGABRDGABRA1 | |
| SCHEMBL4385665 | 0.82 | GRIN1 (0.42) | GRIN1GRIN2BGABRPGABRDGABRA1 | |
| SCHEMBL20327027 | 0.80 | GABRA1 (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL19303482 | 0.80 | LMNA (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1173075 | 0.79 | GRIN1 (0.41) | GRIN1GRIN2BGABRPGABRDGABRA1 | |
| SCHEMBL22072638 | 0.79 | GABRP (0.46) | GRIN1GRIN2BGABRPGABRDGABRA1 | |
| SCHEMBL28139742 | 0.79 | GRIN1 (0.41) | GRIN1GRIN2BGABRPGABRDGABRA1 | |
| SCHEMBL23344350 | 0.79 | GRIN1 (0.40) | GRIN1GRIN2BGABRPGABRDGABRA1 | |
| SCHEMBL16189824 | 0.79 | GABRP (0.47) | GRIN1GRIN2BGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048300-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2020-02-13 | — | — | US | disclosed |
| US-20180179247-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048300-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | NR3C2, HSD3B1, NR3C1 | GRIN1 62/4885GRIN2B 28/4885GABRP 153/4885 |
| US-20180179247-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | CNR1, NR3C2, CNR2 | GRIN1 64/4885GRIN2B 17/4885GABRP 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.