Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.43 |
| ▸ | RARB | P10826 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1636049 | 0.89 | TRPA1 (0.46) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL18084307 | 0.88 | TRPA1 (0.41) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL9205463 | 0.85 | TRPA1 (0.40) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL2039596 | 0.85 | RARB (0.45) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL9953603 | 0.84 | TRPA1 (0.44) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL16606707 | 0.84 | TRPA1 (0.44) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL10044179 | 0.84 | TRPA1 (0.44) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL18084338 | 0.81 | TRPA1 (0.43) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL13554953 | 0.79 | ALDH1A1 (0.41) | TRPA1RARBRARGRXRARARA | |
| SCHEMBL9202801 | 0.77 | TRPA1 (0.42) | TRPA1RARBRARGRXRARARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268346-B1 | PROCESSES FOR THE PREPARATION OF UNSATURATED MALONATES | INT FLAVORS & FRAGRANCES INC (US) | 2021-05-05 | — | — | EP | disclosed |
| US-10358415-B2 | Processes for the preparation of unsaturated malonates | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2019-07-23 | — | — | US | disclosed |
| EP-2513030-B2 | BETA-GAMMA UNSATURATED ESTERS AND PROCESS OF PRODUCTION OF BETA-GAMMA UNSATURATED ESTERS. | GIVAUDAN SA (CH) | 2018-08-29 | — | — | EP | disclosed |
| US-20180105490-A1 | PROCESSES FOR THE PREPARATION OF UNSATURATED MALONATES | INTERNATIONAL FLAVORS AND FRAGRANCES INC. | 2018-04-19 | — | — | US | disclosed |
| US-20180105490-A1 | PROCESSES FOR THE PREPARATION OF UNSATURATED MALONATES | INTERNATIONAL FLAVORS AND FRAGRANCES INC. | 2018-04-19 | — | — | US | disclosed |
| WO-2016145288-A1 | PROCESSES FOR THE PREPARATION OF UNSATURATED MALONATES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2016-09-15 | — | — | WO | disclosed |
| EP-2513030-B1 | BETA-GAMMA UNSATURATED ESTERS AND PROCESS OF PRODUCTION OF BETA-GAMMA UNSATURATED ESTERS. | GIVAUDAN SA (CH) | 2015-05-06 | — | — | EP | disclosed |
| US-8765980-B2 | Organic compounds | GIVAUDAN S.A. (CH) | 2014-07-01 | — | — | US | disclosed |
| US-8765980-B2 | Organic compounds | GIVAUDAN S.A. (CH) | 2014-07-01 | — | — | US | disclosed |
| US-8765980-B2 | Organic compounds | GIVAUDAN S.A. (CH) | 2014-07-01 | — | — | US | disclosed |
| US-20120271059-A1 | Organic Compounds | GIVAUDAN SA (CH) | 2012-10-25 | — | — | US | disclosed |
| US-20120271059-A1 | Organic Compounds | GIVAUDAN SA (CH) | 2012-10-25 | — | — | US | disclosed |
| US-20120271059-A1 | Organic Compounds | GIVAUDAN SA (CH) | 2012-10-25 | — | — | US | disclosed |
| EP-2513030-A1 | ORGANIC COMPOUNDS | Givaudan SA (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073387-A1 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073387-A1 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10358415-B2 | Processes for the preparation of unsaturated malonates | ME1, ACSL6, MAL2 | TRPA1 4202/4885RARB 87/4885RARG 92/4885 |
| US-20120271059-A1 | Organic Compounds | HSD17B12, HSD17B1, MAL2 | TRPA1 2304/4885RARB 408/4885RARG 568/4885 |
| US-20180105490-A1 | PROCESSES FOR THE PREPARATION OF UNSATURATED MALONATES | ME1, ACSL6, MAL2 | TRPA1 4202/4885RARB 87/4885RARG 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.