Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.42 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 7/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 7/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 7/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029278 | 0.98 | SIGMAR1 (0.43) | SIGMAR1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3892949 | 0.79 | SIGMAR1 (0.43) | SIGMAR1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3889734 | 0.79 | SIGMAR1 (0.43) | SIGMAR1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3906553 | 0.79 | SIGMAR1 (0.43) | SIGMAR1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3892951 | 0.79 | SIGMAR1 (0.43) | SIGMAR1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7538877 | 0.71 | SIGMAR1 (0.55) | SIGMAR1HTR1A | |
| SCHEMBL8060721 | 0.70 | MTNR1A (0.36) | SIGMAR1HTR1AKDM4EALDH1A1LMNA | |
| SCHEMBL1969755 | 0.69 | HTR1A (0.62) | SIGMAR1HTR1A | |
| SCHEMBL31046300 | 0.69 | HTR1A (0.62) | SIGMAR1HTR1A | |
| SCHEMBL1971780 | 0.69 | HTR1A (0.62) | SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741962-B2 | Process for preparation of Rasagiline and salts thereof | USV LIMITED (IN) | 2014-06-03 | — | — | US | claimed |
| EP-2364967-A2 | Process for preparation of rasagiline and salts thereof | USV Limited (IN) | 2011-09-14 | — | — | EP | claimed |
| US-20110155626-A1 | PROCESS FOR PREPARATION OF RASAGILINE AND SALTS THEREOF | USV LIMITED (IN) | 2011-06-30 | — | — | US | claimed |
| US-8741962-B2 | Process for preparation of Rasagiline and salts thereof | USV LIMITED (IN) | 2014-06-03 | — | — | US | disclosed |
| EP-2364967-A2 | Process for preparation of rasagiline and salts thereof | USV Limited (IN) | 2011-09-14 | — | — | EP | disclosed |
| US-20110155626-A1 | PROCESS FOR PREPARATION OF RASAGILINE AND SALTS THEREOF | USV LIMITED (IN) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110155626-A1 | PROCESS FOR PREPARATION OF RASAGILINE AND SALTS THEREOF | RAB27A, RAB35, RAB7A | SIGMAR1 3861/4885HTR1A 1838/4885SLC6A2 865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.