Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 7/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PRNP | P04156 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20340181 | 0.87 | KMT2A (0.42) | ACMSDCYP2C19KDM4EKMT2AMAPT | |
| SCHEMBL23852405 | 0.87 | ACMSD (0.52) | ACMSDCYP2C19KDM4EPIM1KMT2A | |
| SCHEMBL24088040 | 0.86 | ACMSD (0.44) | ACMSDCYP2C19KDM4EPIM1KMT2A | |
| SCHEMBL20339912 | 0.86 | ACMSD (0.44) | ACMSDCYP2C19KDM4EKMT2AMEN1 | |
| SCHEMBL24088014 | 0.84 | ACMSD (0.68) | ACMSDCYP2C19KDM4EPIM1KMT2A | |
| SCHEMBL20339819 | 0.84 | BRD4 (0.40) | ACMSDCYP2C19KDM4EKMT2AMAPT | |
| SCHEMBL26404249 | 0.83 | ALDH1A1 (0.47) | ACMSDCYP2C19KDM4EKMT2AMAPT | |
| SCHEMBL32688007 | 0.82 | ACMSD (0.49) | ACMSDKMT2AALDH1A1MEN1ADORA2A | |
| SCHEMBL20340099 | 0.81 | KMT2A (0.40) | ACMSDCYP2C19KDM4EKMT2AMAPT | |
| SCHEMBL20340093 | 0.81 | KDM4E (0.48) | ACMSDCYP2C19KDM4EPIM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12378200-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2025-08-05 | — | — | US | disclosed |
| US-20250145572-A1 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors | ORSOBIO INC (US) | 2025-05-08 | — | — | US | disclosed |
| US-20240059657-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | OrsoBio Inc. | 2024-02-22 | — | — | US | disclosed |
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20210094916-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ORSOBIO, INC. | 2021-04-01 | — | — | US | disclosed |
| US-20210094916-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ORSOBIO, INC. | 2021-04-01 | — | — | US | disclosed |
| WO-2018125983-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| WO-2018125983-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12378200-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ALDH7A1, ACMSD, AMD1 | ACMSD 2/4885CYP2C19 644/4885KDM4E 1040/4885 |
| US-20250145572-A1 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors | ACMSD, ALDH7A1, ALAD | ACMSD 1/4885CYP2C19 471/4885KDM4E 807/4885 |
| US-20240059657-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ALDH7A1, ACMSD, AMD1 | ACMSD 2/4885CYP2C19 644/4885KDM4E 1040/4885 |
| US-20210094916-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ALDH7A1, OTC, DDC | ACMSD 8/4885CYP2C19 727/4885KDM4E 1198/4885 |
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ALDH7A1, ACMSD, AMD1 | ACMSD 2/4885CYP2C19 644/4885KDM4E 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.