Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 5/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20341767 | 0.85 | ABL1 (0.37) | PDE7BRAB9AABL1NPC1HSD11B1 | |
| SCHEMBL20341827 | 0.82 | ABL1 (0.37) | PDE7BRAB9AABL1NPC1HSD11B1 | |
| SCHEMBL18616834 | 0.81 | CTSL (0.45) | — | |
| SCHEMBL23810302 | 0.78 | GSK3B (0.40) | RAB9AABL1NPC1 | |
| SCHEMBL18615931 | 0.77 | CTSS (0.36) | PDE7BRAB9A | |
| SCHEMBL18615938 | 0.74 | CTSL (0.37) | — | |
| SCHEMBL18615936 | 0.72 | MAOA (0.33) | RAB9AABL1NPC1HSD11B1 | |
| SCHEMBL20341862 | 0.72 | BMPR1B (0.36) | RAB9ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL23810222 | 0.71 | NPC1 (0.48) | RAB9ANPC1TP53 | |
| SCHEMBL23810294 | 0.71 | TACR2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342765-A1 | CATHEPSIN K INHIBITOR AND APPLICATION THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2018-07-04 | — | — | EP | disclosed |