Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20341862 | 0.82 | BMPR1B (0.36) | NPC1KMT2ARAB9AMEN1LMNA | |
| SCHEMBL18615936 | 0.82 | MAOA (0.33) | NPC1KMT2ARAB9AMEN1LMNA | |
| SCHEMBL18617379 | 0.82 | NPC1 (0.42) | NPC1KMT2ARAB9AMEN1LMNA | |
| SCHEMBL18615951 | 0.80 | BMPR1B (0.35) | NPC1KMT2ARAB9AMEN1LMNA | |
| SCHEMBL20341831 | 0.79 | MAPT (0.32) | KMT2ARAB9AMEN1MAPTALDH1A1 | |
| SCHEMBL20341745 | 0.75 | SMN1; SMN2 (0.42) | NPC1KMT2ARAB9AMEN1LMNA | |
| SCHEMBL23810304 | 0.74 | RAB9A (0.39) | NPC1KMT2ARAB9AMEN1LMNA | |
| SCHEMBL18615914 | 0.74 | MAPT (0.31) | NPC1KMT2ARAB9AMEN1MAPT | |
| SCHEMBL18616494 | 0.73 | CTSL (0.43) | POLBNAMPT | |
| SCHEMBL20341790 | 0.73 | NAMPT (0.42) | NPC1KMT2ARAB9AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342765-B1 | CATHEPSIN K INHIBITOR AND APPLICATION THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2021-09-15 | — | — | EP | disclosed |