Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344807 | 0.90 | P2RX7 (0.33) | P2RX7 | |
| SCHEMBL17039255 | 0.81 | CLK1 (0.40) | MAPTMAPK1P2RX3 | |
| SCHEMBL17039306 | 0.78 | FABP4 (0.35) | P2RX7MAPT | |
| SCHEMBL17039251 | 0.74 | P2RX3 (0.36) | P2RX3AVPR1B | |
| SCHEMBL17029066 | 0.74 | P2RX3 (0.36) | P2RX3AVPR1B | |
| SCHEMBL17029065 | 0.74 | P2RX3 (0.36) | P2RX3AVPR1B | |
| SCHEMBL17039259 | 0.74 | NR1I2 (0.39) | PDE4BMAPTMAPK1AVPR1B | |
| SCHEMBL17039247 | 0.73 | KDM4E (0.40) | THRBMAPTCNR2 | |
| SCHEMBL17029018 | 0.73 | NR1I2 (0.40) | — | |
| SCHEMBL18364987 | 0.73 | CLK1 (0.35) | P2RX3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107913-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2018-07-04 | — | — | EP | disclosed |