Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 9/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14124402 | 0.83 | IMPDH2 (0.64) | RAB9ANPC1CYP3A4MAOBMAOA | |
| SCHEMBL20353518 | 0.81 | MEN1 (0.70) | RAB9ANPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19241846 | 0.79 | IMPDH2 (0.49) | MAPTKMT2AMEN1IMPDH2ROCK2 | |
| SCHEMBL20353541 | 0.77 | RAB9A (0.67) | RAB9ANPC1MAPTSMN1; SMN2TP53 | |
| SCHEMBL20353539 | 0.77 | RAB9A (0.67) | RAB9ANPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20353520 | 0.76 | CYP3A4 (0.52) | RAB9ANPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20524931 | 0.75 | CYP3A4 (0.57) | RAB9ANPC1CYP3A4MAPTKMT2A | |
| SCHEMBL20524933 | 0.75 | CYP3A4 (0.57) | RAB9ANPC1CYP3A4MAPTKMT2A | |
| SCHEMBL20353592 | 0.75 | IMPDH2 (0.62) | NOTUMIMPDH2ROCK2 | |
| SCHEMBL4280508 | 0.75 | RAB9A (1.00) | RAB9ANPC1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | ALCON INC. (CH) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | COQ8A, PGC, AGK | RAB9A 568/4885NPC1 510/4885CYP1A2 3076/4885 |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | COQ8A, PGC, AGK | RAB9A 568/4885NPC1 510/4885CYP1A2 3076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.