Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 5/20 | 0.62 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14124402 | 0.81 | IMPDH2 (0.64) | IMPDH2PRMT3ROCK1ROCK2 | |
| SCHEMBL24735962 | 0.79 | IMPDH2 (0.69) | IMPDH2PRMT3ROCK1ROCK2NOTUM | |
| SCHEMBL3566775 | 0.78 | PRMT3 (0.72) | IMPDH2PRMT3ROCK1ROCK2NOTUM | |
| SCHEMBL20353578 | 0.77 | IMPDH2 (0.80) | IMPDH2PRMT3ROCK1ROCK2 | |
| SCHEMBL2162998 | 0.77 | IMPDH2 (1.00) | IMPDH2PRMT3ROCK1ROCK2 | |
| SCHEMBL12058848 | 0.76 | POLB (0.65) | IMPDH2PRMT3ROCK1ROCK2NOTUM | |
| SCHEMBL2164137 | 0.76 | PRMT3 (0.69) | IMPDH2PRMT3ROCK1ROCK2NOTUM | |
| SCHEMBL20353445 | 0.75 | RAB9A (0.67) | IMPDH2ROCK2NOTUM | |
| SCHEMBL20353575 | 0.75 | IMPDH2 (1.00) | IMPDH2PRMT3ROCK1ROCK2 | |
| SCHEMBL22857554 | 0.75 | ROCK2 (0.57) | IMPDH2PRMT3ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | ALCON INC. (CH) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | COQ8A, PGC, AGK | IMPDH2 2131/4885PRMT3 1026/4885ROCK1 375/4885 |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | COQ8A, PGC, AGK | IMPDH2 2131/4885PRMT3 1026/4885ROCK1 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.