Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | CDK4 | P11802 | 4/20 | 0.63 |
| ▸ | CCND1 | P24385 | 4/20 | 0.63 |
| ▸ | HTR6 | P50406 | 2/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060777 | 0.82 | HTR2C (1.00) | HTR2AHTR2CCDK4CCND1HTR6 | |
| SCHEMBL29372496 | 0.80 | CDK4 (0.76) | HTR2AHTR2CCDK4CCND1HTR6 | |
| SCHEMBL3595410 | 0.80 | CDK4 (0.76) | HTR2AHTR2CCDK4CCND1HTR6 | |
| SCHEMBL11366447 | 0.79 | CDK4 (1.00) | HTR2AHTR2CCDK4CCND1HTR6 | |
| SCHEMBL3393613 | 0.79 | HTR2A (0.59) | HTR2AHTR2CCDK4CCND1MAPK1 | |
| SCHEMBL7745745 | 0.78 | PKM (0.57) | HTR2AHTR2CMAPK1HTTLMNA | |
| Iodide SCHEMBL2581030 | 0.78 | CDK4 (0.73) | HTR2AHTR2CCDK4CCND1HTR6 | |
| SCHEMBL4007913 | 0.78 | SCN9A (0.55) | HTR2AHTR2CHTR6SCN9AMAPK1 | |
| SCHEMBL7256513 | 0.78 | HTR7 (0.51) | HTR2AHTR2CHTR6SCN9AHTR1D | |
| SCHEMBL3935119 | 0.78 | SCN9A (0.55) | HTR2AHTR2CCDK4CCND1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516419-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-10-31 | — | — | EP | disclosed |
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| WO-2011079102-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079102-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |
| CN-100558355-C | Indole-5 sulfamide derivative and preparation and its purposes as the 5-HT-6 regulator | ESTEVE LABOR DR (ES) | 2009-11-11 | — | — | CN | disclosed |
| CN-1832740-A | Indol-5 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators | ESTEVE LABOR DR (ES) | 2006-09-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | TPSAB1, TPSB2, TPSD1 | HTR2A 32/4885HTR2C 52/4885CDK4 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.